The rare daily word game sweeping the globe. Find what's hidden in plain sight.
PRION
Definition of PRION
noun
A self-propagating misfolded conformer of a protein that is responsible for a number of diseases that affect the brain and other neural tissue.
Wiktionary · CC BY-SA
Where it comes from
From (a reordering of) the initial letters of proteinaceous infectious particle. Coined by American neurologist and biochemist Stanley B. Prusiner in 1982.
Etymology via Wiktionary (CC BY-SA).
OUTLIER scores every word on how unusual it is, and that number is not published. Working it out at the board is the game.
PRION in OUTLIER
Players have found it on 43 boards so far. 135 players have found it across Outlier's history.
It first turned up on Day 8, 29 May 2026. The most recent board was Day 102, 30 August 2026. It was on the latest finished board.
First found by a player on Day 8, 29 May 2026.
Built from these letters
PRION starts with P and ends with N. Sorted, its letters read INOPR - the shape to hunt for when the grid is scrambled. No letter is used twice, which makes it an isogram.
Same letters, different word
2 other words use exactly these letters. Worth knowing at the board: an anagram fits a grid the same way.
Also seen on Day 8
Could you have found PRION?
OUTLIER is a daily word game. One grid, the same grid for everybody, and the words nobody else spots are the ones that pay. This word was on Day 8 - and most players walked straight past it.
Play today's OUTLIER